In people with type 1 diabetes even relatively low levels of self-reported exercise are associated with a less adverse vascular risk profile — ASN Events
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In people with type 1 diabetes even relatively low levels of self-reported exercise are associated with a less adverse vascular risk profile (#162)

Daniel Seller 1 , Andrzej S Januszewski 2 , David N O'Neal 1 , Connie S Karschimkus 1 , Kevin G Rowley 1 , Mark Hargreaves 3 , Alicia J Jenkins 1
  1. Department of Medicine, University of Melbourne, Fitzroy, VIC, Australia
  2. NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW, Australia
  3. Department of Physiology, University of Melbourne, Parkville, VIC, Australia
Exercise is vasoprotective, yet people with Type 1 diabetes (T1D) often avoid exercise as it can induce high and low glucose levels, and they are generally less physically fit than their non-diabetic peers. T1D is associated with stiffer arteries and higher cardiovascular event rates. We related self-reported exercise to vascular health and vascular risk factors in 236 T1D patients (aged 18–77 yrs, mean±SD T1D duration 21±14 yrs, 86 with vascular complications) and 253 age-matched healthy controls (CON). HbA1c was 8.0±1.4% and 5.1±0.4% in T1D and CON respectively (p<0.00001). Exercise intensity was based on frequency of ≥20 min. heavy or light physical activity in the preceding week: not at all, <3 or ≥3 times. Results were adjusted for age, BMI and GFR. In CON intensive exercise ≥3/week vs. less exercise was associated with lower myeloperoxidase 61.5±10.6 vs. 101.5±10.2 µg/l; p=0.007 and increased total NO (28.6±3.3 vs. 18.6±2.8 µmol/l; p=0.009). Mild exercise was not associated with any biomarker differences. In T1D intense exercise ≥3/ week vs. less was associated with lower LDL-C (2.6±0.1 vs. 2.9±0.1mmol/l; p=0.02), higher HDL-C (1.6±0.1 vs. 1.5±0.1mmol/l; p=0.05) and Large Artery Elasticity (19.3±0.8 vs. 16.0±0.7ml/mmHg x10; p=0.002). In T1D mild physical activity ≥3/ week vs. less exercise was associated with lower hsCRP (1.44±1.10mg/l vs. 2.09±1.12mg/l;p=0.02). In T1D physical exercise is associated with better vascular health and a less adverse risk factor profile.